Detail

Keywords

Biomimetic Materials; Nerve Regeneration; Schwann Cells; Silk

Research group(s)

• ARGE Radtke
  Research Area: cell based therapies and spider silk conduits for peripheral nerve regeneration
  Members:
  Paul Supper
  Flavia Millesi
  Tamara Weiss
  Maximilian Haertinger
  Sarah Isabella Stadlmayr
  Aida Naghilou

Research interests

My research involves characterization of native spider silk for finding a correlation between its material properties and its success in supporting peripheral nerve regeneration. I am also interested in employing spectroscopical methods for quantification of nerve regeneration. In addition, I use ultrashort pulsed lasers for precise and targeted production of functional materials with tailored properties.

Techniques, methods & infrastructure

• Raman Spectroscopy
• Scanning Electron Microscopy (SEM)
• Atomic Force Microscopy (AFM)
• Ultrafast Lasers and Optics
• Laser Patterning for Biomimetic Materials Production
• Production of Nanoparticles for Multimodal Imaging Applications
• Primary Rodent Cell Culture
• Live Cell Imaging
• Confocal Microscopy
• Scanning Probe Microscopy
• Single-Cell Mechanics and Rheological Properties
• Biomolecular Condensates
• Fluorescence Recovery After Photobleaching (FRAP)

Grants

• Understanding the acceptance of spider silk by Schwann cells (2020)
  Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
  Coordinator of the collaborative project

Selected publications

1. Naghilou, A., Armbruster, O. and Mashaghi, A. (2025) ‘Scanning probe microscopy elucidates gelation and rejuvenation of biomolecular condensates’, Cell Reports Physical Science, 6(2), p. 102430. Available at: https://doi.org/10.1016/j.xcrp.2025.102430.
2. Stadlmayr, S. et al. (2023) ‘Comparative Analysis of Various Spider Silks in Regard to Nerve Regeneration: Material Properties and Schwann Cell Response’, Advanced Healthcare Materials, 13(8). Available at: https://doi.org/10.1002/adhm.202302968.
3. Naghilou, A. et al. (2023) ‘Insights into the material properties of dragline spider silk affecting Schwann cell migration’, International Journal of Biological Macromolecules, 244, p. 125398. Available at: https://doi.org/10.1016/j.ijbiomac.2023.125398.
4. Semmler, L. et al. (2023) ‘Silk‐in‐Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model’, Advanced Healthcare Materials, 12(11). Available at: https://doi.org/10.1002/adhm.202203237.
5. Naghilou, A. et al. (2020) ‘Correlating the secondary protein structure of natural spider silk with its guiding properties for Schwann cells’, Materials Science and Engineering: C, 116, p. 111219. Available at: https://doi.org/10.1016/j.msec.2020.111219.