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Detail

Cecile Philippe
Mag. Dr. Cecile PhilippeHead of Radiopharmacy and Experimental Nuclear Medicine

Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: Research Associate (Postdoc)

T +43 1 40400 20340
cecile.philippe@meduniwien.ac.at

Further Information

Keywords

Drug Evaluation, Preclinical; Molecular Imaging; Positron-Emission Tomography; Radioactive Tracers

Research group(s)

  • Radiopharmacy and Experimental Nuclear Medicine

Research interests

The main focus of my research is the PET (positron emisson tomography) tracer development for the MCHR1 (melanin concentrationg hormone receptor 1). This target is of high interest for endocrinological diseases such as obesity od diabetes. A PET tracer would provide deeper understanding of the MCHR1 functions and could help to better understand the endocrine status and guide pharmacological intervention via the MCHR1.

Techniques, methods & infrastructure

Drug development techniques:

  • Radiosynthesis
  • Binding-studies
  • Metabolism
  • Blood-brain-barrier penetration
  • Autoradiography
  • Immunhistochemistry
  • Small animal PET
  • Biodistribution

 

Selected publications

  1. Philippe, C. et al., 2013. Preclinical in vitro & in vivo evaluation of [11C]SNAP-7941 - the first PET tracer for the melanin concentrating hormone receptor 1. Nuclear Medicine and Biology, 40(7), pp.919-925. Available at: http://dx.doi.org/10.1016/j.nucmedbio.2013.05.010.
  2. Philippe, C. et al., 2012. [18F]FE@SNAP - A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches. Bioorganic & Medicinal Chemistry, 20(19), pp.5936-5940. Available at: http://dx.doi.org/10.1016/j.bmc.2012.07.051.
  3. Philippe, C. et al., 2014. Comparative autoradiographic in vitro investigation of melanin concentrating hormone receptor 1 ligands in the central nervous system. European Journal of Pharmacology, 735, pp.177-183. Available at: http://dx.doi.org/10.1016/j.ejphar.2014.04.020.
  4. Philippe, C. et al., 2011. Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB). Applied Radiation and Isotopes, 69(9), pp.1212-1217. Available at: http://dx.doi.org/10.1016/j.apradiso.2011.04.010.
  5. Philippe, C. et al., 2015. Parameter evaluation and fully-automated radiosynthesis of [11C]harmine for imaging of MAO-A for clinical trials. Applied Radiation and Isotopes, 97, pp.182-187. Available at: http://dx.doi.org/10.1016/j.apradiso.2015.01.002.