Colorectal Neoplasms; Colorectal Surgery
- Surgical Research Laboratories
Head: Michael Bergmann
Research Area: The task of the laboratory is to combine molecular/cellular biology and the needs posed by surgical patients. Thus, the laboratory acts at the interface between clinical medicine and basic research, promoting translational medical science.
After finishing my PhD focussing on transplant immunology and metabolic changes in end-stage liver disease/portal hypertension, my interest has evolved into the field of cancer- and immunometabolism.
My current research focus aims to better understand metabolic rewiring in stem cells during cancer development and to investigate the impact of secreted oncometabolites on tumor-infiltrating immune cells.
Techniques, methods & infrastructure
Basic research techniques/models:
- Standard molecular biology techniques
- CRISPR/Cas9 gene editing
- Murine in vivo models
- Intestinal organoids
- Confocal microscopy
- Establishment, maintenance and analysis of large clinical prospective and retrospective databases
- Establishment and maintenance of a colorectal cancer biobank
- Impact of mesenteric lymph drainage in antigen presentation in Crohn’s disease (2020)
Source of Funding: City of Vienna, inflammatory bowel disease
- The role of FAMIN in cancer development (2019)
Source of Funding: FWF (Austrian Science Fund), Schroedinger Fellowship
- Knight, S.R. et al., 2021. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries. The Lancet, 397(10272), pp.387–397. Available at: http://dx.doi.org/10.1016/S0140-6736(21)00001-5.
- Cader, M.Z. et al., 2020. FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle. Cell, 180(2), pp.278–295.e23. Available at: http://dx.doi.org/10.1016/j.cell.2019.12.017.
- Unger, L.W. et al., 2019. Mesenteric granulomas independently predict long‐term risk of surgical recurrence in Crohn’s disease. Colorectal Disease, 22(2), pp.170–177. Available at: http://dx.doi.org/10.1111/codi.14814.
- Unger, L.W. et al., 2018. Effect of pathologist’s dedication on lymph node detection rate and postoperative survival in colorectal cancer. Colorectal Disease, 20(7), pp.O173–O180. Available at: http://dx.doi.org/10.1111/codi.14241.
- Unger, L.W. et al., 2019. Guideline-conform statin use reduces overall mortality in patients with compensated liver disease. Scientific Reports, 9(1). Available at: http://dx.doi.org/10.1038/s41598-019-47943-6.