Dr. Gabriela K. Muschitz, PhD
MedUni Vienna RESEARCHER OF THE MONTH, May 2017
Severe burn injury causes a massive and prolonged stress response.
This study investigated early and prolonged changes of serum bone turnover markers (BTM) and regulators of bone metabolism. Thirty two male patients with a median age of 40.5 years and a median burned total body surface area (TBSA) of 40% were included.
During the early phase pronounced increases were observed for CTX, P1NP, sclerostin, DKK-1, BALP, FGF23 and iPTH levels, whereas 25-OH vitamin D, albumin, serum and ionized calcium levels decreased.
In the prolonged phase (day 21 – 56), changes of P1NP were most pronounced, followed by elevated sclerostin, OCN, BALP, and lesser changes for albumin levels. In contrast levels of iPTH, FGF23, CRP and to a lesser extent CTX and phosphate levels, declined significantly during this phase of investigation.
Ongoing changes of BTM and regulators of bone metabolism suggest alterations in bone metabolism with a likely adverse influence on bone quality and structure in male patients with severe burn injuries.
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7. Pomper G, Trescher K, Santer D, Hasun M, Baumgartner A, Adelmann K, Inci M, Dietl W, Zuckermann AO, Podesser BK. Introducing a mouse model of brain death. J Neurosci Methods. 2010 Sep 30;192(1):70-4.
8. Kremer J, Muschitz GK, Aumayr K, Moser P, Szabo G, Weymann A, Zuckermann A, Podesser BK. Influence of antithymocyte globulin treatment of brain-dead organ donor on inflammatory response in cardiac grafts: an experimental study in mice. Transpl Int. 2016 Dec;29(12):1329-1336.