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January 2020 - Roman Reindl-Schwaighofer

Dr. Roman Reindl-Schwaighofer

MedUni Wien RESEARCHER OF THE MONTH January 2020

Contribution of non-HLA incompatibility between donor and recipient to kidney allograft survival: genome-wide analysis in a prospective cohort

Recognition of non-self-structures on donor cells represents the main immunological barrier in solid organ transplantation. The Human Leucocyte Antigens (HLA) are considered the most important “non-self” antigens in transplantation. Long-term graft loss is mainly caused by the formation of alloreactive antibodies that are directed against non-self-structures on cell surface proteins. Our study for the first time provides evidence for a similar importance of non-HLA mismatches between donors and recipients for long-term kidney allograft survival. These data suggest a broader concept of immunological non-self that goes beyond HLA incompatibility and expands the current concept of polymorphic “non-self” epitopes on cell surface molecules from HLA to non-HLA targets. Amino acid substitutions caused by single nucleotide variants in protein coding represent the basis for polymorphic residues in both HLA and non-HLA molecules.

Selected Literature

  1. Reindl-Schwaighofer, R., et al. Contribution of non-HLA incompatibility between donor and recipient to kidney allograft survival: genome-wide analysis in a prospective cohort. Lancet, 2019 (IF=59.102)
  2. Reindl-Schwaighofer, R., et al. A novel inside-out access approach for hemodialysis catheter placement in patients with thoracic central venous occlusion. American Journal of Kidney Disease, 2019 (IF=6.653)
  3. Reindl-Schwaighofer, R., et al., Steroid pretreatment of organ donors does not impact on early rejection and long-term kidney allograft survival: Results from a multicenter randomized, controlled trial. Am Journal of Transplantation, 2019 (IF=7.163)
  4. Reindl-Schwaighofer, R., et al., Novel insights into Non-HLA Alloimmunity in Kidney Transplantation. Transplant International, 2019 (IF=3.562)
  5. Reindl-Schwaighofer, R., et al. Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection. New England Journal of Medicine, 2019 (IF=70.670)
  6. Reindl-Schwaighofer, R., et al. Histocompatibility: minor differences have a major impact. Nat Rev Nephrol, 2019 (IF=19.684)

Dr. Roman Reindl-Schwaighofer

Dr. Roman Reindl-Schwaighofer
Klinische Abteilung für Nephrologie und Dialyse
Univ. Klinik für Innere Medizin II
Medizinische Universität Wien
A-1090 Wien, Währinger Gürtel 18-20

T: +43 (1) 40400-43910
roman.reindl-schwaighofer@meduniwien.ac.at

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